【广东会GDH基因检测】外泌体微小RNA介导的肿瘤微环境中胰腺癌细胞与癌症相关成纤维细胞之间的影响

肿瘤基因检测哪家机构贼好导读

根据影响肿瘤风险及靶向药物治疗效果的因素高峰论坛，《Int J Mol Sci》在. 2022 Aug 23;23(17):9512.发表了一篇题目为《外泌体微小RNA介导的肿瘤微环境中胰腺癌细胞与癌症相关成纤维细胞之间的串扰》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Xiangyu Chu, Yinmo Yang, Xiaodong Tian 等完成。促进了肿瘤的正确治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及正确治疗临床研究内容关键词：

数据中心,癌症相关成纤维细胞,外泌体 miRNA,肿瘤微环境

肿瘤靶向治疗基因检测临床应用结果

胰腺导管腺癌（PDAC）是恶性程度贼高的消化道肿瘤之一，具有早期诊断率低、侵袭性强、转移早等特点。 胰腺导管腺癌中丰富的基质细胞、致密的细胞外基质和血液供应不足限制了化疗药物的渗透，导致目前的治疗方案疗效不佳。癌症相关成纤维细胞 (CAF) 是肿瘤微环境中的主要基质细胞。肿瘤细胞可以分泌外泌体促进活化CAFs的产生，同时癌症相关成纤维细胞分泌的外泌体有助于促进肿瘤进展。外泌体中miRNAs的异常表达参与了肿瘤细胞与癌症相关成纤维细胞的相互作用，这为外泌体miRNAs在胰腺导管腺癌诊断和治疗中的应用提供了可能。本文综述了肿瘤微环境中胰腺导管腺癌细胞与CAFs串扰中外泌体miRNA的作用机制，以期加深对TME调控的认识，并为设计针对人胰腺导管腺癌中外泌体miRNA的诊断和治疗靶点提供依据。关键词：PDAC ;癌症相关成纤维细胞；外泌体 miRNA；肿瘤微环境。

肿瘤发生与反复转移国际数据库描述：

Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant digestive tumors, characterized by a low rate of early diagnosis, strong invasiveness, and early metastasis. The abundant stromal cells, dense extracellular matrix, and lack of blood supply in PDAC limit the penetration of chemotherapeutic drugs, resulting in poor efficacy of the current treatment regimens. Cancer-associated fibroblasts (CAFs) are the major stromal cells in the tumor microenvironment. Tumor cells can secrete exosomes to promote the generation of activated CAFs, meanwhile exosomes secreted by CAFs help promote tumor progression. The aberrant expression of miRNAs in exosomes is involved in the interaction between tumor cells and CAFs, which provides the possibility for the application of exosomal miRNAs in the diagnosis and treatment of PDAC. The current article reviews the mechanism of exosomal miRNAs in the crosstalk between PDAC cells and CAFs in the tumor microenvironment, in order to improve the understanding of TME regulation and provide evidence for designing diagnostic and therapeutic targets against exosome miRNA in human PDAC.Keywords: PDAC; cancer-associated fibroblasts; exosomal miRNAs; tumor microenvironment.